Shopping road gravel bikes can quickly become a choice between a straightforward road setup and a feature-rich endurance build. Here, the Cannondale Synapse Carbon Endurance Road Bike is the lower-priced 51 cm option with rim caliper brakes, while the Trek Domane SL5 Carbon Endurance is a 56 cm disc-brake bike with wider 700x32 tires set up tubeless. Frame size and brake preference should lead the decision.
Quick verdict
Choose the Cannondale Synapse Carbon Endurance Road Bike - Size 51cm if a 51 cm frame, full-carbon frame and fork, drop bars, and a mixed Shimano 10-speed drivetrain suit your plans. Its listed price is USD 517.00.
Choose the Trek Domane SL5 Carbon Endurance 56cm Road Bike Disc Brake 2023 if you want the listed 56 cm frame, disc brakes, Shimano 105 R7020 11-speed equipment, internal storage, fender mounts, and 700x32 tires set up tubeless. Its listed price is USD 3,500.00.
At-a-glance comparison
| Detail | Cannondale Synapse Carbon Endurance | Trek Domane SL5 Carbon Endurance |
|---|---|---|
| Listed price | USD 517.00 | USD 3,500.00 |
| Frame size | 51 cm | 56 cm |
| Brake setup | Rim caliper | Disc brake |
| Drivetrain | Mixed Shimano 10-speed; Shimano Sora front derailleur | Shimano 105 R7020, 11-speed |
| Tire setup | 700x25c road tires | 700x32, set up tubeless |
| Useful listed equipment | FSA Gossamer compact 50/34T crankset | Internal storage, fender mounts, two carbon seat posts |
Where each bike wins
The Cannondale is the more direct choice for someone whose required frame size is 51 cm and who wants a compact 50/34T crankset for easier climbing. Its full-carbon frame and fork, carbon compliance seatpost, and 700x25c road tires make it a focused endurance-road configuration.
The Trek is better aligned with a rider seeking its particular equipment list: a 56 cm carbon frame, disc brakes, 11-speed Shimano 105 R7020 drivetrain, internal frame bag, and fender mounts. The supplied short and tall carbon seat posts also give the owner two seatpost options.
Cannondale Synapse Carbon Endurance Road Bike - Size 51cm

Pick the Cannondale Synapse when a 51 cm endurance road bike is the appropriate size and you prefer its uncomplicated road-oriented specification. The full-carbon frame and fork pair with a Cannondale carbon compliance seatpost, while the mixed Shimano 10-speed drivetrain includes a Shimano Sora front derailleur and an FSA Gossamer compact crankset with 50/34T rings. That combination gives this black, used bike a clear focus on fitness riding, commuting, and longer road rides. Its main constraint is equally clear: it uses rim caliper brakes and 700x25c road tires. Riders specifically looking for disc brakes or the Trek's 700x32 tubeless setup should lean toward the Domane instead.
Trek Domane SL5 Carbon Endurance 56cm Road Bike Disc Brake 2023

The Trek Domane SL5 makes sense when the listed 56 cm frame is your required size and its extra on-bike provisions matter to you. Its 500 Series OCLV Carbon frame includes IsoSpeed, internal cable routing, internal storage, a 3S chain keeper, fender mounts, and a 142x12 mm thru axle. Shimano 105 R7020 11-speed equipment and Bontrager Paradigm alloy wheels complement the 700x32 tubeless tire setup. This gray, used bike also includes both short and tall carbon seat posts. One practical limitation is that pedals are not included. It is also a substantially higher-priced choice, so its frame size and specific equipment should be central to the decision.
Final choice by use case
Choose the Cannondale Synapse for a 51 cm carbon endurance road bike with a compact 50/34T crankset, rim caliper brakes, and 700x25c road tires. Choose the Trek Domane SL5 for a 56 cm carbon endurance bike when disc brakes, 11-speed Shimano 105 R7020, internal storage, fender mounts, and a 700x32 tubeless setup better match your intended riding.